Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
USERS' SCORE
Good
Based on 4 Reviews
8.4
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Proprietary Probiotic BlendLacticaseibacillus rhamnosus R0011Lactobacillus helvetius R0052Pediococcus acidilactici R1001Lacticaseibacillus casei R0215Bifidobacterium longum BB536Lactiplantibacillus plantarum R1012Bifidobacterium breve R0070Lactococcus lactis subsp. lactis R1058
131 mg (10 Billion CFU)
†
Top Medical Research Studies
8
Probiotics effectively prevent UTIs
We evaluated how probiotics could help prevent recurrent urinary tract infections (UTIs) in premenopausal women. In our study, 174 women were randomly assigned to different treatment groups, including a placebo and various probiotic combinations over four months. After tracking symptoms for a year, we found that using vaginal probiotics, alone or combined with oral ones, effectively reduced episodes of symptomatic UTIs. This suggests probiotics may be a promising non-antibiotic approach to managing recurrent UTIs.
Read More
8
We examined how the GAI98322 strain of Lactobacillus crispatus can help in preventing recurrent cystitis. Through tests on its cell-free culture supernatant, we found that it effectively reduces the growth and biofilm formation of various harmful bacteria, including E. coli and Pseudomonas aeruginosa.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
Read More
8
We explored the use of 3D bioprinted catheters to deliver Lactobacillus rhamnosus as a potential preventative measure against catheter-associated urinary tract infections (CAUTIs). In our assessment, the bioprints successfully supported the growth and viability of L. rhamnosus under simulated urine flow conditions. Remarkably, this probiotic managed to colonize the bladder without causing tissue inflammation.
Our findings suggest that these bioprinted probiotic catheters could be a promising new approach to help combat CAUTIs, offering a safe and effective strategy to reduce pathogen colonization in urinary catheters.
Our findings suggest that these bioprinted probiotic catheters could be a promising new approach to help combat CAUTIs, offering a safe and effective strategy to reduce pathogen colonization in urinary catheters.
Read More
Most Useful Reviews
9
IBS relief achieved
26 people found this helpful
I’ve been using these probiotics to treat my IBS symptoms for a few months, and I’m delighted to report that my symptoms have completely vanished. Additionally, since I began using them, I haven't experienced any urinary tract infections, which were frequent before. Even after stopping the probiotics for four months, my IBS symptoms have not returned. I highly recommend this to anyone struggling with IBS or its symptoms.
Read More
9
Yeast infection improvement
15 people found this helpful
I have tried various probiotic formulas as I often suffer from urinary tract infections and was weary of expensive over-the-counter creams. So far, this product has been effective! Another bonus is that I avoided a terrible flu that affected my whole family; I can’t be certain if this helped, but I'd like to think so. I will continue taking it!
Read More
7.5
Chronic issues addressed
9 people found this helpful
I believe this product helps with issues such as urinary tract infections and chronic constipation in women. I take two capsules each morning with dietary fibre and aloe gel. I’ve noticed an improvement in my vaginitis and overall intestinal health. I intend to keep using these probiotics, as they seem to enhance my body's immunity effectively.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.1
- All Researches
9
We investigated the effectiveness of probiotics sourced from Bulgarian cheese and shallot yogurt against common bacteria causing urinary tract infections (UTIs).
By isolating 100 strains from clinical samples and testing various probiotic strains, we found that certain probiotics showed encouraging antibacterial and antibiofilm activity.
Notably, strains M and B indicated strong antimicrobial effects without any harmful qualities. While these results are promising, we recognize that further research is essential to fully assess their therapeutic potential for UTIs.
By isolating 100 strains from clinical samples and testing various probiotic strains, we found that certain probiotics showed encouraging antibacterial and antibiofilm activity.
Notably, strains M and B indicated strong antimicrobial effects without any harmful qualities. While these results are promising, we recognize that further research is essential to fully assess their therapeutic potential for UTIs.
Read More
9
We investigated how by-products from Lactobacillus rhamnosus can affect uropathogenic Escherichia coli (UPEC), the bacteria commonly responsible for urinary tract infections (UTIs). Our findings revealed that lactic acid, hydrogen peroxide, and other compounds from these probiotics significantly inhibited the growth of UPEC.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
Additionally, they reduced the production of proteins that help the bacteria cling to the urinary tract. This suggests that Lactobacillus rhamnosus and its by-products offer protective benefits against UTIs by combating harmful bacteria and reducing their ability to establish infections.
Read More
8
Dietary supplement improves UTI outcomes
We examined the effects of a specific supplement, combining Lactobacillus strains with proanthocyanidin-rich extracts from cranberry and cinnamon, on recurrent urinary tract infections (UTIs) in women.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
Read More
8
Probiotics effectively prevent UTIs
We evaluated how probiotics could help prevent recurrent urinary tract infections (UTIs) in premenopausal women. In our study, 174 women were randomly assigned to different treatment groups, including a placebo and various probiotic combinations over four months. After tracking symptoms for a year, we found that using vaginal probiotics, alone or combined with oral ones, effectively reduced episodes of symptomatic UTIs. This suggests probiotics may be a promising non-antibiotic approach to managing recurrent UTIs.
Read More
8
We examined how the GAI98322 strain of Lactobacillus crispatus can help in preventing recurrent cystitis. Through tests on its cell-free culture supernatant, we found that it effectively reduces the growth and biofilm formation of various harmful bacteria, including E. coli and Pseudomonas aeruginosa.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
This action is facilitated by specific factors, which work independently of traditional antibiotics. While our findings highlight the potential of Lactobacillus in managing recurrent infections, further studies are essential to confirm its effectiveness in clinical settings.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
IBS relief achieved
26 people found this helpful
I’ve been using these probiotics to treat my IBS symptoms for a few months, and I’m delighted to report that my symptoms have completely vanished. Additionally, since I began using them, I haven't experienced any urinary tract infections, which were frequent before. Even after stopping the probiotics for four months, my IBS symptoms have not returned. I highly recommend this to anyone struggling with IBS or its symptoms.
Read More
9
Yeast infection improvement
15 people found this helpful
I have tried various probiotic formulas as I often suffer from urinary tract infections and was weary of expensive over-the-counter creams. So far, this product has been effective! Another bonus is that I avoided a terrible flu that affected my whole family; I can’t be certain if this helped, but I'd like to think so. I will continue taking it!
Read More
7.5
Chronic issues addressed
9 people found this helpful
I believe this product helps with issues such as urinary tract infections and chronic constipation in women. I take two capsules each morning with dietary fibre and aloe gel. I’ve noticed an improvement in my vaginitis and overall intestinal health. I intend to keep using these probiotics, as they seem to enhance my body's immunity effectively.
Read More
2
No changes observed
I did not notice any changes regarding my digestive tract after using this product. It did not help with my urinary tract infection or constipation.
Read More
Frequently Asked Questions
9
IBS relief achieved
26 people found this helpful
I’ve been using these probiotics to treat my IBS symptoms for a few months, and I’m delighted to report that my symptoms have completely vanished. Additionally, since I began using them, I haven't experienced any urinary tract infections, which were frequent before. Even after stopping the probiotics for four months, my IBS symptoms have not returned. I highly recommend this to anyone struggling with IBS or its symptoms.
9
Yeast infection improvement
15 people found this helpful
I have tried various probiotic formulas as I often suffer from urinary tract infections and was weary of expensive over-the-counter creams. So far, this product has been effective! Another bonus is that I avoided a terrible flu that affected my whole family; I can’t be certain if this helped, but I'd like to think so. I will continue taking it!
2
No changes observed
I did not notice any changes regarding my digestive tract after using this product. It did not help with my urinary tract infection or constipation.
7.5
Chronic issues addressed
9 people found this helpful
I believe this product helps with issues such as urinary tract infections and chronic constipation in women. I take two capsules each morning with dietary fibre and aloe gel. I’ve noticed an improvement in my vaginitis and overall intestinal health. I intend to keep using these probiotics, as they seem to enhance my body's immunity effectively.
8
Dietary supplement improves UTI outcomes
We examined the effects of a specific supplement, combining Lactobacillus strains with proanthocyanidin-rich extracts from cranberry and cinnamon, on recurrent urinary tract infections (UTIs) in women.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
In our controlled study with 80 participants over six months, we compared those taking the supplement to a non-supplemented group.
The results were striking: 64.9% of women on the supplement didn't experience any cystitis episodes, versus just 31.6% of those without. Additionally, the supplement significantly improved symptom severity and quality of life.
8
Probiotics effectively prevent UTIs
We evaluated how probiotics could help prevent recurrent urinary tract infections (UTIs) in premenopausal women. In our study, 174 women were randomly assigned to different treatment groups, including a placebo and various probiotic combinations over four months. After tracking symptoms for a year, we found that using vaginal probiotics, alone or combined with oral ones, effectively reduced episodes of symptomatic UTIs. This suggests probiotics may be a promising non-antibiotic approach to managing recurrent UTIs.
7
We examined whether probiotics could prevent urinary tract infections (UTIs) in premenopausal women, given the rise in antibiotic resistance. By reviewing existing studies from 2001 to 2021 that compared probiotics to a placebo, we aimed to find out how effective these supplements are at reducing UTI recurrence.
Unfortunately, our analysis revealed no significant benefit of probiotics in preventing UTIs in this group. This suggests that, while investigating alternatives is crucial, probiotics may not be the solution we hoped for in addressing recurrent UTIs.
Unfortunately, our analysis revealed no significant benefit of probiotics in preventing UTIs in this group. This suggests that, while investigating alternatives is crucial, probiotics may not be the solution we hoped for in addressing recurrent UTIs.
7
Combination therapy shows promise
We explored the effectiveness of a combination of cranberries, Lactobacillus rhamnosus, and vitamin C in treating recurrent urinary tract infections (UTIs) in women. In our pilot study, 42 women took these supplements daily for 20 days, and follow-up evaluations were conducted at three and six months.
Of the participants, 72.2% and 61.1% were symptom-free at the three and six-month marks, respectively, making this approach a potentially safe and effective option for UTI management. Importantly, no major side effects were reported throughout the study.
Of the participants, 72.2% and 61.1% were symptom-free at the three and six-month marks, respectively, making this approach a potentially safe and effective option for UTI management. Importantly, no major side effects were reported throughout the study.
8
We examined the potential of Lactobacillus probiotics to fend off recurrent urinary tract infections (UTIs) in females. By analyzing nine clinical trials involving 726 patients, we found that certain strains, particularly Lactobacillus rhamnosus and Lactobacillus reuteri, might effectively reduce the risk of recurrent UTIs.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
While results are promising, with a notably lower risk ratio of recurrent episodes, it's important to note the presence of significant variability between studies and short follow-up times. This calls for further, more rigorous research to confirm these benefits and establish standardized practices in the future.
References
- Ait Abdellah S, Leblanc A, Dauchet Q, Blondeau C, Bohbot JM. Effects of a supplement associating strains and proanthocyanidin-rich plant extracts against recurrent uncomplicated, urinary tract infections: A prospective, controlled study. Investig Clin Urol. 2025;66:36. doi:10.4111/icu.20240092
- Amigh P, Ahmadi Y, Mohkam M, Shokri D. Antimicrobial Potential of Probiotic Strains From Bulgarian Cheese and Shallot Yogurt Against . Biomed Res Int. 2024;2024:2978083. doi:10.1155/2024/2978083
- Bimbatti KF, Rocha RDS, Braido IZ, Lima IC, Benoso P, et al. Development and evaluation of fermented milk with Lactobacillus acidophilus added to concentrated cranberry (Vaccinium macrocarpon) juice with the potential to minimize the recurrence of urinary tract infections. Food Res Int. 2024;195:114997. doi:10.1016/j.foodres.2024.114997
- Daniel M, Szymanik-Grzelak H, Sierdziński J, Pańczyk-Tomaszewska M. PL1 and PM1 versus Placebo as Prophylaxis for Recurrence of Urinary Tract Infections in Children. Microorganisms. 2024;12. doi:10.3390/microorganisms12061037
- Gupta V, Mastromarino P, Garg R. Effectiveness of Prophylactic Oral and/or Vaginal Probiotic Supplementation in the Prevention of Recurrent Urinary Tract Infections: A Randomized, Double-Blind, Placebo-Controlled Trial. Clin Infect Dis. 2024;78:1154. doi:10.1093/cid/ciad766
- Shoureshi PS, Niino C, Eilber KS. Can vaginal lactobacillus suppositories help reduce urinary tract infections?. Int Urogynecol J. 2023;34:2713. doi:10.1007/s00192-023-05568-4
- Watanabe T, Sadahira T, Hirakawa H, Huang P, Zhou T, et al. Exploration of the protein-dependent mechanism of Lactobacillus crispatus GAI98322 to prevent recurrent cystitis. J Infect Chemother. 2023;29:1001. doi:10.1016/j.jiac.2023.06.013
- Das S, Konwar BK. Prophylactic application of vaginal lactic acid bacteria against urogenital pathogens and its prospective use in sanitary suppositories. Int Microbiol. 2024;27:179. doi:10.1007/s10123-023-00376-8
- Meštrović Popovič K, Povalej Bržan P, Langerholc T, Marčun Varda N. The Impact of Lactobacillus Plantarum PCS26 Supplementation on the Treatment and Recurrence of Urinary Tract Infections in Children-A Pilot Study. J Clin Med. 2022;11. doi:10.3390/jcm11237008
- Soltani N, Abbasi S, Baghaeifar S, Taheri E, Farhoudi Sefidan Jadid M, et al. Antibacterial and antibiofilm activity of Lactobacillus strains secretome and extraction against isolated from urinary tract infection. Biotechnol Rep (Amst). 2022;36:e00760. doi:10.1016/j.btre.2022.e00760
- Emami E, Mt Sherwin C, Heidari-Soureshjani S. Effect of Probiotics on Urinary Tract Infections in Children: A Systematic Review and Meta-Analysis. Curr Rev Clin Exp Pharmacol. 2023;19:111. doi:10.2174/2772432817666220501114505
- Abdullatif VA, Sur RL, Eshaghian E, Gaura KA, Goldman B, et al. Efficacy of Probiotics as Prophylaxis for Urinary Tract Infections in Premenopausal Women: A Systematic Review and Meta-Analysis. Cureus. 2021;13:e18843. doi:10.7759/cureus.18843
- Kyser AJ, Greiner A, Harris V, Patel R, Frieboes HB, et al. 3D-Bioprinted Urinary Catheters Enable Sustained Probiotic Recovery Under Flow and Improve Bladder Colonization In Vivo. Probiotics Antimicrob Proteins. 2025. doi:10.1007/s12602-024-10428-8
- Ghane M, Babaeekhou L, Ketabi SS. Antibiofilm Activity of Kefir Probiotic Lactobacilli Against Uropathogenic (UPEC). Avicenna J Med Biotechnol. 2020;12:221.
- Sadeghi-Bojd S, Naghshizadian R, Mazaheri M, Ghane Sharbaf F, Assadi F. Efficacy of Probiotic Prophylaxis After The First Febrile Urinary Tract Infection in Children With Normal Urinary Tracts. J Pediatric Infect Dis Soc. 2020;9:305. doi:10.1093/jpids/piz025
- Toh SL, Lee BB, Ryan S, Simpson JM, Clezy K, et al. Probiotics [LGG-BB12 or RC14-GR1] versus placebo as prophylaxis for urinary tract infection in persons with spinal cord injury [ProSCIUTTU]: a randomised controlled trial. Spinal Cord. 2019;57:550. doi:10.1038/s41393-019-0251-y
- Kara SS, Volkan B, Erten I. GG can protect malnourished children. Benef Microbes. 2019;10:237. doi:10.3920/BM2018.0071
- Ng QX, Peters C, Venkatanarayanan N, Goh YY, Ho CYX, et al. Use of Lactobacillus spp. to prevent recurrent urinary tract infections in females. Med Hypotheses. 2018;114:49. doi:10.1016/j.mehy.2018.03.001
- Shim YH, Lee SJ, Lee JW. Antimicrobial activity of lactobacillus strains against uropathogens. Pediatr Int. 2016;58:1009. doi:10.1111/ped.12949
- Montorsi F, Gandaglia G, Salonia A, Briganti A, Mirone V. Effectiveness of a Combination of Cranberries, Lactobacillus rhamnosus, and Vitamin C for the Management of Recurrent Urinary Tract Infections in Women: Results of a Pilot Study. Eur Urol. 2016;70:912. doi:10.1016/j.eururo.2016.05.042
- Manzoor A, Ul-Haq I, Baig S, Qazi JI, Seratlic S. Efficacy of Locally Isolated Lactic Acid Bacteria Against Antibiotic-Resistant Uropathogens. Jundishapur J Microbiol. 2016;9:e18952. doi:10.5812/jjm.18952
- Lee JW, Lee JH, Sung SH, Lee SJ. Preventive effects of Lactobacillus mixture on experimental E. coli urinary tract infection in infant rats. Yonsei Med J. 2013;54:489. doi:10.3349/ymj.2013.54.2.489
- Beerepoot MA, ter Riet G, Nys S, van der Wal WM, de Borgie CA, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Arch Intern Med. 2012;172:704. doi:10.1001/archinternmed.2012.777
- Karlsson M, Scherbak N, Khalaf H, Olsson PE, Jass J. Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-κB activity in Escherichia coli-stimulated urinary bladder cells. FEMS Immunol Med Microbiol. 2012;66:147. doi:10.1111/j.1574-695X.2012.00994.x
- Cadieux PA, Burton J, Devillard E, Reid G. Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli. J Physiol Pharmacol. 2009;60 Suppl 6:13.
- Anukam KC, Hayes K, Summers K, Reid G. Probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 may help downregulate TNF-Alpha, IL-6, IL-8, IL-10 and IL-12 (p70) in the neurogenic bladder of spinal cord injured patient with urinary tract infections: a two-case study. Adv Urol. 2009;2009:680363. doi:10.1155/2009/680363
- Falagas ME, Betsi GI, Tokas T, Athanasiou S. Probiotics for prevention of recurrent urinary tract infections in women: a review of the evidence from microbiological and clinical studies. Drugs. 2006;66:1253.
